AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for clustering and activation of procaspase-1. Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-conta...

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Hlavní autoři: Sagulenko, V, Thygesen, S J, Sester, D P, Idris, A, Cridland, J A, Vajjhala, P R, Roberts, T L, Schroder, K, Vince, J E, Hill, J M, Silke, J, Stacey, K J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741496/
https://ncbi.nlm.nih.gov/pubmed/23645208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.37
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