AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for clustering and activation of procaspase-1. Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-conta...

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Detalhes bibliográficos
Main Authors: Sagulenko, V, Thygesen, S J, Sester, D P, Idris, A, Cridland, J A, Vajjhala, P R, Roberts, T L, Schroder, K, Vince, J E, Hill, J M, Silke, J, Stacey, K J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741496/
https://ncbi.nlm.nih.gov/pubmed/23645208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.37
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