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Molecular Mechanism for p202-mediated Specific Inhibition of AIM2 Inflammasome Activation
Mouse p202 containing two HIN domains antagonizes AIM2 inflammasome signaling and potentially modifies lupus susceptibility. We found only HIN1 of p202 binds dsDNA, while HIN2 forms a homo-tetramer. Crystal structures of HIN1 revealed that dsDNA is bound on the opposite face to the site used in AIM2...
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| Glavni autori: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3760141/ https://ncbi.nlm.nih.gov/pubmed/23850291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.06.024 |
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