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The structure of XIAP BIR2: understanding the selectivity of the BIR domains
XIAP, a member of the inhibitor of apoptosis family of proteins, is a critical regulator of apoptosis. Inhibition of the BIR domain–caspase interaction is a promising approach towards treating cancer. Previous work has been directed towards inhibiting the BIR3–caspase-9 interaction, which blocks the...
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| Autori principali: | , , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
International Union of Crystallography
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3760131/ https://ncbi.nlm.nih.gov/pubmed/23999295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444913016284 |
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