The structure of XIAP BIR2: understanding the selectivity of the BIR domains

XIAP, a member of the inhibitor of apoptosis family of proteins, is a critical regulator of apoptosis. Inhibition of the BIR domain–caspase interaction is a promising approach towards treating cancer. Previous work has been directed towards inhibiting the BIR3–caspase-9 interaction, which blocks the...

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Bibliografiske detaljer
Main Authors: Lukacs, Christine, Belunis, Charles, Crowther, Robert, Danho, Waleed, Gao, Lin, Goggin, Barry, Janson, Cheryl A., Li, Shirley, Remiszewski, Stacy, Schutt, Andrew, Thakur, Manish K., Singh, Saroj K., Swaminathan, Srinivasan, Pandey, Rajat, Tyagi, Rajiv, Gosu, Ramachandraiah, Kamath, Ajith V., Kuglstatter, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2013
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760131/
https://ncbi.nlm.nih.gov/pubmed/23999295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444913016284
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