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pH-Triggered Conformational Switching along the Membrane Insertion Pathway of the Diphtheria Toxin T-Domain

The translocation (T)-domain plays a key role in the action of diphtheria toxin and is responsible for transferring the catalytic domain across the endosomal membrane into the cytosol in response to acidification. Deciphering the molecular mechanism of pH-dependent refolding and membrane insertion o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Ladokhin, Alexey S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760040/
https://ncbi.nlm.nih.gov/pubmed/23925141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins5081362
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