Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

Heat shock protein 90 (Hsp90) is an essential molecular chaperone in eukaryotes that facilitates the conformational maturation and function of a diverse protein clientele, including aberrant and/or over-expressed proteins that are involved in cancer growth and survival. A role for Hsp90 in supportin...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Beebe, Kristin, Mollapour, Mehdi, Scroggins, Bradley, Prodromou, Chrisostomos, Xu, Wanping, Tokita, Mari, Taldone, Tony, Pullen, Lester, Zierer, Bettina K., Lee, Min-Jung, Trepel, Jane, Buchner, Johannes, Bolon, Daniel, Chiosis, Gabriela, Neckers, Leonard
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2013
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759666/
https://ncbi.nlm.nih.gov/pubmed/23867252
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