Positional Scanning Mutagenesis of α-Conotoxin PeIA Identifies Critical Residues That Confer Potency and Selectivity for α6/α3β2β3 and α3β2 Nicotinic Acetylcholine Receptors

The nicotinic acetylcholine receptor (nAChR) subtype α6β2* (the asterisk denotes the possible presence of additional subunits) has been identified as an important molecular target for the pharmacotherapy of Parkinson disease and nicotine dependence. The α6 subunit is closely related to the α3 subuni...

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Autors principals: Hone, Arik J., Ruiz, Miguel, Scadden, Mick'l, Christensen, Sean, Gajewiak, Joanna, Azam, Layla, McIntosh, J. Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757205/
https://ncbi.nlm.nih.gov/pubmed/23846688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482059
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