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PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors

Pharmacologically distinguishing α3β2 nicotinic acetylcholine receptors (nAChRs) from closely related subtypes, particularly α6β2, has been challenging due to the lack of subtype-selective ligands. We created analogs of α-conotoxin (α-Ctx) PeIA to identify ligand–receptor interactions that could be...

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Publicado en:J Med Chem
Autores principales: Hone, Arik J., Fisher, Fernando, Christensen, Sean, Gajewiak, Joanna, Larkin, David, Whiteaker, Paul, McIntosh, J. Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342494/
https://ncbi.nlm.nih.gov/pubmed/31194549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00566
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