α-Conotoxin PeIA[S9H,V10A,E14N] Potently and Selectively Blocks α6β2β3 versus α6β4 Nicotinic Acetylcholine Receptors

Nicotinic acetylcholine receptors (nAChRs) containing α6 and β2 subunits modulate dopamine release in the basal ganglia and are therapeutically relevant targets for treatment of neurological and psychiatric disorders including Parkinson's disease and nicotine dependence. However, the expression...

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Главные авторы: Hone, Arik J., Scadden, Mick'l, Gajewiak, Joanna, Christensen, Sean, Lindstrom, Jon, McIntosh, J. Michael
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477225/
https://ncbi.nlm.nih.gov/pubmed/22914547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080853
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