Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

Nicotinic acetylcholine receptors (nAChRs) containing α6 and β4 subunits are expressed by dorsal root ganglion neurons and have been implicated in neuropathic pain. Rodent models are often used to evaluate the efficacy of analgesic compounds, but species differences may affect the activity of some n...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Hone, Arik J., Talley, Todd T., Bobango, Janet, Huidobro Melo, Cesar, Hararah, Fuaad, Gajewiak, Joanna, Christensen, Sean, Harvey, Peta J., Craik, David J., McIntosh, J. Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240866/
https://ncbi.nlm.nih.gov/pubmed/30249616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005649
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