Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

Nicotinic acetylcholine receptors (nAChRs) containing α6 and β4 subunits are expressed by dorsal root ganglion neurons and have been implicated in neuropathic pain. Rodent models are often used to evaluate the efficacy of analgesic compounds, but species differences may affect the activity of some n...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Hone, Arik J., Talley, Todd T., Bobango, Janet, Huidobro Melo, Cesar, Hararah, Fuaad, Gajewiak, Joanna, Christensen, Sean, Harvey, Peta J., Craik, David J., McIntosh, J. Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240866/
https://ncbi.nlm.nih.gov/pubmed/30249616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005649
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