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PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors

Pharmacologically distinguishing α3β2 nicotinic acetylcholine receptors (nAChRs) from closely related subtypes, particularly α6β2, has been challenging due to the lack of subtype-selective ligands. We created analogs of α-conotoxin (α-Ctx) PeIA to identify ligand–receptor interactions that could be...

詳細記述

保存先:
書誌詳細
出版年:J Med Chem
主要な著者: Hone, Arik J., Fisher, Fernando, Christensen, Sean, Gajewiak, Joanna, Larkin, David, Whiteaker, Paul, McIntosh, J. Michael
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342494/
https://ncbi.nlm.nih.gov/pubmed/31194549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00566
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