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A two-stage Bayesian design with sample size reestimation and subgroup analysis for phase II binary response trials
Frequentist sample size determination for binary outcome data in a two-arm clinical trial requires initial guesses of the event probabilities for the two treatments. Misspecification of these event rates may lead to a poor estimate of the necessary sample size. In contrast, the Bayesian approach tha...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3757106/ https://ncbi.nlm.nih.gov/pubmed/23583925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2013.03.011 |
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