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Optimizing Sample Size Allocation and Power in a Bayesian Two-Stage Drop-The-Losers Design

When a researcher desires to test several treatment arms against a control arm, a two-stage adaptive design can be more efficient than a single-stage design where patients are equally allocated to all treatment arms and the control. We see this type of approach in clinical trials as a seamless Phase...

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Bibliografski detalji
Izdano u:Am Stat
Glavni autori: Karanevich, Alex, Meier, Richard, Graw, Stefan, McGlothlin, Anna, Gajewski, Byron
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517602/
https://ncbi.nlm.nih.gov/pubmed/32981939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00031305.2019.1610065
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