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Blinded and unblinded sample size reestimation in crossover trials balanced for period

The determination of the sample size required by a crossover trial typically depends on the specification of one or more variance components. Uncertainty about the value of these parameters at the design stage means that there is often a risk a trial may be under‐ or overpowered. For many study desi...

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Detalles Bibliográficos
Publicado en:Biom J
Main Authors: Grayling, Michael J., Mander, Adrian P., Wason, James M. S.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175184/
https://ncbi.nlm.nih.gov/pubmed/30073679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201700092
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