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A Trivariate Continual Reassessment Method for Phase I/II Trials of Toxicity, Efficacy, and Surrogate Efficacy
Recently, many Bayesian methods have been developed for dose-finding when simultaneously modeling both toxicity and efficacy outcomes in a blended phase I/II fashion. A further challenge arises when all the true efficacy data cannot be obtained quickly after the treatment, so that surrogate markers...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532950/ https://ncbi.nlm.nih.gov/pubmed/22807126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5477 |
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