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A Trivariate Continual Reassessment Method for Phase I/II Trials of Toxicity, Efficacy, and Surrogate Efficacy
Recently, many Bayesian methods have been developed for dose-finding when simultaneously modeling both toxicity and efficacy outcomes in a blended phase I/II fashion. A further challenge arises when all the true efficacy data cannot be obtained quickly after the treatment, so that surrogate markers...
שמור ב:
| Main Authors: | , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532950/ https://ncbi.nlm.nih.gov/pubmed/22807126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5477 |
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