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A fluorogenic assay for screening Sirt6 modulators
A fluorogenic high-throughput assay suitable for screening Sirt6 modulators is developed based on the recently discovered efficient activity of Sirt6 to hydrolyze myristoyl lysine. Sirt6 modulators will be useful for investigating the function of Sirt6 and protein lysine fatty acylation.
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3756594/ https://ncbi.nlm.nih.gov/pubmed/23839075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob41138a |
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