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Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies
Sirtuins are a class of enzymes originally identified as nicotinamide adenine dinucleotide (NAD)-dependent protein lysine deacetylases. Among the seven mammalian sirtuins, SIRT1-7, only SIRT1-3 possess efficient deacetylase activity in vitro, whereas SIRT4-7 possess very weak in vitro deacetylase ac...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4894398/ https://ncbi.nlm.nih.gov/pubmed/25704306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08529 |
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