De-acylation Mechanism by SIRT2 Revealed in the 1′-SH-2′-O-myristoyl Intermediate Structure

Sirtuins are NAD-dependent deacylases. Previous studies have established two important enzymatic intermediates in sirtuin-catalyzed deacylation, an alkylamidate intermediate I, which is then converted to a bicyclic intermediate II. However, how intermediate II is converted to products is unknown. Ba...

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Udgivet i:Cell Chem Biol
Main Authors: Wang, Yi, Fung, Yi Man Eva, Zhang, Weizhe, He, Bin, Chung, Matthew Wai Heng, Jin, Jing, Hu, Jing, Lin, Hening, Hao, Quan
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365152/
https://ncbi.nlm.nih.gov/pubmed/28286128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.02.007
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