Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies

Sirtuins are a class of enzymes originally identified as nicotinamide adenine dinucleotide (NAD)-dependent protein lysine deacetylases. Among the seven mammalian sirtuins, SIRT1-7, only SIRT1-3 possess efficient deacetylase activity in vitro, whereas SIRT4-7 possess very weak in vitro deacetylase ac...

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Udgivet i:Sci Rep
Main Authors: Teng, Yan-Bin, Jing, Hui, Aramsangtienchai, Pornpun, He, Bin, Khan, Saba, Hu, Jing, Lin, Hening, Hao, Quan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894398/
https://ncbi.nlm.nih.gov/pubmed/25704306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08529
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