Interplay between TCR Affinity and Necessity of Coreceptor Ligation: High-Affinity Peptide-MHC/TCR Interaction Overcomes Lack of CD8 Engagement()

CD8 engagement is believed to be a critical event in the activation of naive T cells. In this communication, we address the effects of peptide-MHC (pMHC)/TCR affinity on the necessity of CD8 engagement in T cell activation of primary naive cells. Using two peptides with different measured avidities...

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Main Authors: Kerry, Samantha E., Buslepp, Jennifer, Cramer, Lorraine A., Maile, Robert, Hensley, Lucinda L., Nielsen, Alma I., Kavathas, Paula, Vilen, Barbara J., Collins, Edward J., Frelinger, Jeffrey A.
Format: Artigo
Sprog:Inglês
Udgivet: 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755740/
https://ncbi.nlm.nih.gov/pubmed/14568922
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