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Modulation of MHC Binding by Lateral Association of TCR and Coreceptor
The structure of a T cell receptor (TCR) and its affinity for cognate antigen are fixed, but T cells regulate binding sensitivity through changes in lateral membrane organization. TCR microclusters formed upon antigen engagement participate in downstream signaling. Microclusters are also found 3–4 d...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491726/ https://ncbi.nlm.nih.gov/pubmed/23199917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.09.011 |
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