TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune responses. It is driven by specific T-cell antigen receptors (TCRs) binding to antigenic peptide–major histocompatibility complex (pMHC) molecules on other cells1. If productive, these interactions promote the...

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Detalhes bibliográficos
Main Authors: Huppa, Johannes B., Axmann, Markus, Mörtelmaier, Manuel A., Lillemeier, Björn F., Newell, Evan W., Brameshuber, Mario, Klein, Lawrence O., Schütz, Gerhard J., Davis, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273423/
https://ncbi.nlm.nih.gov/pubmed/20164930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08746
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