Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase

The thiazolidinedione, compound 1, has previously shown pan-inhibition of the phosphoinositide 3-kinase (PI3K) class I isoforms. We hypothesized the derivatization of the thiazolidinedione core of compound 1 could introduce isoform selectivity. We report the synthesis, characterization, and inhibito...

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Hlavní autoři: Pinson, Jo-Anne, Schmidt-Kittler, Oleg, Frazzetto, Mark, Zheng, Zhaohua, Jennings, Ian G., Kinzler, Kenneth W., Vogelstein, Bert, Chalmers, David K., Thompson, Philip E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755381/
https://ncbi.nlm.nih.gov/pubmed/23997244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1071/CH12140
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