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Dissecting Isoform Selectivity of PI3 Kinase Inhibitors. The Role of Non-conserved Residues in the Catalytic Pocket
The past few years have seen the identification of numerous small molecules that selectively inhibit specific Class I isoforms of PI3K yet little has been revealed about the molecular basis for the observed selectivities. Using site directed mutagenesis, we have investigated one of the areas postula...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820364/ https://ncbi.nlm.nih.gov/pubmed/18489260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20080512 |
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