Dissecting Isoform Selectivity of PI3 Kinase Inhibitors. The Role of Non-conserved Residues in the Catalytic Pocket

The past few years have seen the identification of numerous small molecules that selectively inhibit specific Class I isoforms of PI3K yet little has been revealed about the molecular basis for the observed selectivities. Using site directed mutagenesis, we have investigated one of the areas postula...

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Main Authors: Frazzetto, Mark, Suphioglu, Cenk, Zhu, Jiuxiang, Schmidt-Kittler, Oleg, Jennings, Ian G., Cranmer, Susan. L., Jackson, Shaun P., Kinzler, Kenneth W., Vogelstein, Bert, Thompson, Philip E.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820364/
https://ncbi.nlm.nih.gov/pubmed/18489260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20080512
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