Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown dependence on expression of the inhibitory FcγR, FcγRIIB. It remains unclear if enga...

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Hlavní autoři: Bulliard, Yannick, Jolicoeur, Rose, Windman, Maurice, Rue, Sarah M., Ettenberg, Seth, Knee, Deborah A., Wilson, Nicholas S., Dranoff, Glenn, Brogdon, Jennifer L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2013
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754864/
https://ncbi.nlm.nih.gov/pubmed/23897982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130573
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