Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions

Engagement of Fcγ-receptors triggers a range of downstream signalling events resulting in a diverse array of immune functions. As a result, blockade of Fc-mediated function is an important strategy for the control of several autoimmune and inflammatory conditions. We have generated a hexameric-Fc fu...

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Udgivet i:Sci Rep
Main Authors: Qureshi, O. S., Rowley, T. F., Junker, F., Peters, S. J., Crilly, S., Compson, J., Eddleston, A., Björkelund, H., Greenslade, K., Parkinson, M., Davies, N. L., Griffin, R., Pither, T. L., Cain, K., Christodoulou, L., Staelens, L., Ward, E., Tibbitts, J., Kiessling, A., Smith, B., Brennan, F. R., Malmqvist, M., Fallah-Arani, F., Humphreys, D. P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719016/
https://ncbi.nlm.nih.gov/pubmed/29213127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17255-8
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