Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown dependence on expression of the inhibitory FcγR, FcγRIIB. It remains unclear if enga...

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Detalhes bibliográficos
Main Authors: Bulliard, Yannick, Jolicoeur, Rose, Windman, Maurice, Rue, Sarah M., Ettenberg, Seth, Knee, Deborah A., Wilson, Nicholas S., Dranoff, Glenn, Brogdon, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754864/
https://ncbi.nlm.nih.gov/pubmed/23897982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130573
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