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HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Hypoxia occurs frequently in human cancers and induces adaptive changes in cell metabolism that include a switch from oxidative phosphorylation to glycolysis, increased glycogen synthesis, and a switch from glucose to glutamine as the major substrate for fatty acid synthesis. This broad metabolic re...
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| Formato: | Artigo |
| Idioma: | Inglês |
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American Society for Clinical Investigation
2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3754249/ https://ncbi.nlm.nih.gov/pubmed/23999440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67230 |
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