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HIF-1: upstream and downstream of cancer metabolism
Hypoxia-inducible factor 1 (HIF-1) plays a key role in the reprogramming of cancer metabolism by activating transcription of genes encoding glucose transporters and glycolytic enzymes, which take up glucose and convert it to lactate; pyruvate dehydrogenase kinase 1, which shunts pyruvate away from t...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822127/ https://ncbi.nlm.nih.gov/pubmed/19942427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2009.10.009 |
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