Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment

Cancers subvert the host immune system to facilitate disease progression. These evolved immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic strategies. Emerging data indicate that local tumor-associated DC populations exhibit tolerogenic features by promoting Treg dev...

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Hauptverfasser: Hanks, Brent A., Holtzhausen, Alisha, Evans, Katherine S., Jamieson, Rebekah, Gimpel, Petra, Campbell, Olivia M., Hector-Greene, Melissa, Sun, Lihong, Tewari, Alok, George, Amanda, Starr, Mark, Nixon, Andrew, Augustine, Christi, Beasley, Georgia, Tyler, Douglas S., Osada, Takayu, Morse, Michael A., Ling, Leona, Lyerly, H. Kim, Blobe, Gerard C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754240/
https://ncbi.nlm.nih.gov/pubmed/23925295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65745
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