Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment

Cancers subvert the host immune system to facilitate disease progression. These evolved immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic strategies. Emerging data indicate that local tumor-associated DC populations exhibit tolerogenic features by promoting Treg dev...

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Detalhes bibliográficos
Main Authors: Hanks, Brent A., Holtzhausen, Alisha, Evans, Katherine S., Jamieson, Rebekah, Gimpel, Petra, Campbell, Olivia M., Hector-Greene, Melissa, Sun, Lihong, Tewari, Alok, George, Amanda, Starr, Mark, Nixon, Andrew, Augustine, Christi, Beasley, Georgia, Tyler, Douglas S., Osada, Takayu, Morse, Michael A., Ling, Leona, Lyerly, H. Kim, Blobe, Gerard C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754240/
https://ncbi.nlm.nih.gov/pubmed/23925295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65745
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