Influenza A Virus Hemagglutinin Trimerization Completes Monomer Folding and Antigenicity

Influenza A virus (IAV) remains an important human pathogen largely because of antigenic drift, the rapid emergence of antibody escape mutants that precludes durable vaccination. The most potent neutralizing antibodies interact with cognate epitopes in the globular “head” domain of hemagglutinin (HA...

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Main Authors: Magadán, Javier G., Khurana, Surender, Das, Suman R., Frank, Gregory M., Stevens, James, Golding, Hana, Bennink, Jack R., Yewdell, Jonathan W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754138/
https://ncbi.nlm.nih.gov/pubmed/23824811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00471-13
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