Influenza A Virus Hemagglutinin Trimerization Completes Monomer Folding and Antigenicity

Influenza A virus (IAV) remains an important human pathogen largely because of antigenic drift, the rapid emergence of antibody escape mutants that precludes durable vaccination. The most potent neutralizing antibodies interact with cognate epitopes in the globular “head” domain of hemagglutinin (HA...

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Autori principali: Magadán, Javier G., Khurana, Surender, Das, Suman R., Frank, Gregory M., Stevens, James, Golding, Hana, Bennink, Jack R., Yewdell, Jonathan W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754138/
https://ncbi.nlm.nih.gov/pubmed/23824811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00471-13
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