Glycan-Dependent Immunogenicity of Recombinant Soluble Trimeric Hemagglutinin

Recombinant soluble trimeric influenza A virus (IAV) hemagglutinin (sHA(3)) has proven an effective vaccine antigen against IAV. Here, we investigate to what extent the glycosylation status of the sHA(3) glycoprotein affects its immunogenicity. Different glycosylation forms of subtype H5 trimeric HA...

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Main Authors: de Vries, Robert P., Smit, Cornelis H., de Bruin, Erwin, Rigter, Alan, de Vries, Erik, Cornelissen, Lisette A. H. M., Eggink, Dirk, Chung, Nancy P. Y., Moore, John P., Sanders, Rogier W., Hokke, Cornelis H., Koopmans, Marion, Rottier, Peter J. M., de Haan, Cornelis A. M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486279/
https://ncbi.nlm.nih.gov/pubmed/22915811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01084-12
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