Glycan-Dependent Immunogenicity of Recombinant Soluble Trimeric Hemagglutinin

Recombinant soluble trimeric influenza A virus (IAV) hemagglutinin (sHA(3)) has proven an effective vaccine antigen against IAV. Here, we investigate to what extent the glycosylation status of the sHA(3) glycoprotein affects its immunogenicity. Different glycosylation forms of subtype H5 trimeric HA...

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Detalhes bibliográficos
Main Authors: de Vries, Robert P., Smit, Cornelis H., de Bruin, Erwin, Rigter, Alan, de Vries, Erik, Cornelissen, Lisette A. H. M., Eggink, Dirk, Chung, Nancy P. Y., Moore, John P., Sanders, Rogier W., Hokke, Cornelis H., Koopmans, Marion, Rottier, Peter J. M., de Haan, Cornelis A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486279/
https://ncbi.nlm.nih.gov/pubmed/22915811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01084-12
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