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Topological Analysis of HIV-1 Glycoproteins Expressed In Situ on Virus Surfaces Reveals Tighter Packing but Greater Conformational Flexibility than for Soluble gp120

In natural infection, antibodies interact with HIV-1 primarily through nonfunctional forms of envelope glycoproteins (Env), including uncleaved (UNC) gp160 and gp41 stumps. These antigens are important to fully characterize, as they may be decoys that promote nonneutralizing responses and may also b...

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Hlavní autoři: Tong, Tommy, Osawa, Keiko, Robinson, James E., Crooks, Ema T., Binley, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754051/
https://ncbi.nlm.nih.gov/pubmed/23740975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01145-13
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