The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal

Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and double-stranded RNA into ∼21-nt-long products ultimately triggering sequence-dependent gene silencing. Although processing of substrates in vertebrate cells occurs in the cytoplasm, there...

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Main Authors: Doyle, Michael, Badertscher, Lukas, Jaskiewicz, Lukasz, Güttinger, Stephan, Jurado, Sabine, Hugenschmidt, Tabea, Kutay, Ulrike, Filipowicz, Witold
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753931/
https://ncbi.nlm.nih.gov/pubmed/23882114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.039255.113
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