C/EBPγ Suppresses Senescence and Inflammatory Gene Expression by Heterodimerizing with C/EBPβ

C/EBPβ is an important regulator of oncogene-induced senescence (OIS). Here, we show that C/EBPγ, a heterodimeric partner of C/EBPβ whose biological functions are not well understood, inhibits cellular senescence. Cebpg(−/−) mouse embryonic fibroblasts (MEFs) proliferated poorly, entered senescence...

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Autors principals: Huggins, Christopher J., Malik, Radek, Lee, Sook, Salotti, Jacqueline, Thomas, Sara, Martin, Nancy, Quiñones, Octavio A., Alvord, W. Gregory, Olanich, Mary E., Keller, Jonathan R., Johnson, Peter F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753923/
https://ncbi.nlm.nih.gov/pubmed/23775115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01674-12
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