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Ikaros limits basophil development by suppressing C/EBP-α expression
The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing sign...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795458/ https://ncbi.nlm.nih.gov/pubmed/23990620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-494625 |
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