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Ikaros limits basophil development by suppressing C/EBP-α expression

The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing sign...

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Detalhes bibliográficos
Main Authors: Rao, Kavitha N., Smuda, Craig, Gregory, Gregory D., Min, Booki, Brown, Melissa A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795458/
https://ncbi.nlm.nih.gov/pubmed/23990620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-494625
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