3′UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells

C/EBPβ is an auto-repressed protein that becomes post-translationally activated by Ras-MEK-ERK signalling. C/EBPβ is required for oncogene-induced senescence (OIS) of primary fibroblasts, but also displays pro-oncogenic functions in many tumour cells. Here, we show that C/EBPβ activation by H-Ras(V1...

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Detalhes bibliográficos
Main Authors: Basu, Sandip K, Malik, Radek, Huggins, Christopher J, Lee, Sook, Sebastian, Thomas, Sakchaisri, Krisada, Quiñones, Octavio A, Alvord, W Gregory, Johnson, Peter F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173785/
https://ncbi.nlm.nih.gov/pubmed/21804532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.250
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