Wird geladen...
C/EBPβ cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence
In primary cells, overexpression of oncogenes such as Ras(V12) induces premature senescence rather than transformation. Senescence is an irreversible form of G(1) arrest that requires the p19(ARF)/p53 and p16(INK4a)/pRB pathways and may suppress tumorigenesis in vivo. Here we show that the transcrip...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2005
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224679/ https://ncbi.nlm.nih.gov/pubmed/16107878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600789 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|