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C/EBPβ cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence
In primary cells, overexpression of oncogenes such as Ras(V12) induces premature senescence rather than transformation. Senescence is an irreversible form of G(1) arrest that requires the p19(ARF)/p53 and p16(INK4a)/pRB pathways and may suppress tumorigenesis in vivo. Here we show that the transcrip...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224679/ https://ncbi.nlm.nih.gov/pubmed/16107878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600789 |
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