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C/EBPβ cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence

In primary cells, overexpression of oncogenes such as Ras(V12) induces premature senescence rather than transformation. Senescence is an irreversible form of G(1) arrest that requires the p19(ARF)/p53 and p16(INK4a)/pRB pathways and may suppress tumorigenesis in vivo. Here we show that the transcrip...

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Bibliografiske detaljer
Main Authors: Sebastian, Thomas, Malik, Radek, Thomas, Sara, Sage, Julien, Johnson, Peter Frederick
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224679/
https://ncbi.nlm.nih.gov/pubmed/16107878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600789
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