MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts

The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. How...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Zhang, Fan, Zakaria, Siti Mariam, Högqvist Tabor, Vedrana, Singh, Madhurendra, Tronnersjö, Susanna, Goodwin, Jacob, Selivanova, Galina, Bartek, Jiri, Castell, Alina, Larsson, Lars-Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343716/
https://ncbi.nlm.nih.gov/pubmed/30526305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1553339
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