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MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts
The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. How...
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| Udgivet i: | Cell Cycle |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6343716/ https://ncbi.nlm.nih.gov/pubmed/30526305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1553339 |
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