MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts

The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. How...

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發表在:Cell Cycle
Main Authors: Zhang, Fan, Zakaria, Siti Mariam, Högqvist Tabor, Vedrana, Singh, Madhurendra, Tronnersjö, Susanna, Goodwin, Jacob, Selivanova, Galina, Bartek, Jiri, Castell, Alina, Larsson, Lars-Gunnar
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2018
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343716/
https://ncbi.nlm.nih.gov/pubmed/30526305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1553339
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