MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts

The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. How...

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Udgivet i:Cell Cycle
Main Authors: Zhang, Fan, Zakaria, Siti Mariam, Högqvist Tabor, Vedrana, Singh, Madhurendra, Tronnersjö, Susanna, Goodwin, Jacob, Selivanova, Galina, Bartek, Jiri, Castell, Alina, Larsson, Lars-Gunnar
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343716/
https://ncbi.nlm.nih.gov/pubmed/30526305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1553339
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