The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling

NAD(+) is an important co-factor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylase. We show that NAD(+) levels are reduced in aged mice and C. elegans and that decreasing NAD(+) levels results in a further reduction in worm lifespan. Conversely, genetic or pharmaco...

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Main Authors: Mouchiroud, Laurent, Houtkooper, Riekelt H., Moullan, Norman, Katsyuba, Elena, Ryu, Dongryeol, Cantó, Carles, Mottis, Adrienne, Jo, Young-Suk, Viswanathan, Mohan, Schoonjans, Kristina, Guarente, Leonard, Auwerx, Johan
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753670/
https://ncbi.nlm.nih.gov/pubmed/23870130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.016
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