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It takes two to tango: NAD(+) and sirtuins in aging/longevity control

The coupling of nicotinamide adenine dinucleotide (NAD(+)) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD(+) and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulatio...

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Detalhes bibliográficos
Publicado no:NPJ Aging Mech Dis
Main Authors: Imai, Shin-ichiro, Guarente, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514996/
https://ncbi.nlm.nih.gov/pubmed/28721271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjamd.2016.17
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