Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels

Human ether-à-go-go–related gene (hERG, Kv11.1) potassium channels have unusually slow activation and deactivation kinetics. It has been suggested that, in fast-activating Shaker channels, a highly conserved Phe residue (F290) in the S2 segment forms a putative gating charge transfer center that int...

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Bibliografiske detaljer
Main Authors: Cheng, Yen May, Hull, Christina M., Niven, Christine M., Qi, Ji, Allard, Charlene R., Claydon, Tom W.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753600/
https://ncbi.nlm.nih.gov/pubmed/23980197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201310992
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