Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer

Accelerated glucose metabolism is a common feature of cancer cells. Hexokinases catalyze the first committed step of glucose metabolism. Hexokinase 2 (HK2) is expressed at high level in cancer cells, but only in a limited number of normal adult tissues. Using Hk2 conditional knockout mice, we showed...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Patra, Krushna C., Wang, Qi, Bhaskar, Prashanth T., Miller, Luke, Wang, Zebin, Wheaton, Will, Chandel, Navdeep, Laakso, Markku, Muller, William J., Allen, Eric L., Jha, Abhishek K., Smolen, Gromoslaw A., Clasquin, Michelle F., Robey, Brooks, Hay, Nissim
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2013
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753022/
https://ncbi.nlm.nih.gov/pubmed/23911236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.06.014
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